Basically the most painful question an interviewer can ask. A friend of mine was laid off on Monday (boo!) but already had two phone interviews this morning (yay!). He claims to have bombed both of them, citing his response the most dreaded question in the history of job interviews: "What is your greatest weakness?" Apparently he said "um" for a minute before the interviewer just moved on. Probably not the best response.
I tend to become overwhelmed if I think I have too many projects going on at once. My solution to this is to create a to-do list so I can see what I have to do still as well as the progress that I've made.The author also offers the funniest answer he's heard: "Kryptonite." And one of the commenters claims to have said "Chocolate cake," which made the interviewers laugh (he was hired). In fact, a funny answer may make you a more memorable candidate if you can provide the interviewers with a genuine chuckle. All the same, best to have a real (and honest!) answer prepared before you show up. Feel free to leave yours in the comments.